GLP-1 Medications
How semaglutide, tirzepatide and retatrutide work, how they compare with other weight-loss peptides, and what the trials measured.
GLP-1 microdosing: what it means
What people mean by "microdosing" semaglutide or tirzepatide, why they try it, what evidence does and does not exist, the dosing risks with compounded vials, and how a doctor's low starting dose differs from a "microdose" protocol.
Does MOTS-c burn visceral fat? What the mouse studies found, and why people try it for weight loss anyway
MOTS-c for weight loss, read against the evidence: what the mouse metabolism studies measured about visceral fat, liver fat and body weight, what the few human data show, how it compares with GLP-1 drugs, why people stack it anyway, side effects, cost context and what the community says.
Peptides for weight loss: what people mean, what works, and what is still a mouse result
An evidence-ranked guide to everything sold or discussed as a peptide for weight loss: semaglutide and tirzepatide, the new oral options, investigational retatrutide, MOTS-c and 5-Amino-1MQ. What each one is, what the human or animal studies measured, side effects, cost, and what the community is actually trying.
Retatrutide vs tirzepatide: is retatrutide just a stronger Mounjaro?
A sourced side-by-side of retatrutide and tirzepatide (Zepbound, Mounjaro): how a triple agonist differs from a dual agonist, what each drug's trials measured, how the side effects compare, where each one stands, and what the forums get right and wrong about 'stronger Mounjaro'.
Semaglutide vs tirzepatide: how they differ and which fits which goal
A sourced, side-by-side comparison of semaglutide and tirzepatide for weight management: how the two mechanisms differ, which brands are which (Wegovy, Ozempic, Zepbound, Mounjaro), what the head-to-head SURMOUNT-5 trial found, how side effects and cost compare, and how a licensed provider decides which one fits your goal.
Tesamorelin for belly fat and weight loss: myth vs evidence
Tesamorelin is the one growth-hormone-axis drug with large trial data on belly fat, but those trials were in adults with HIV-related abdominal fat. What it actually shrank, why its label calls it weight neutral, how it differs from Ozempic and other GLP-1s, and what that means for everyone else asking about it.
How GLP-1 medications work for weight loss
A plain-language explainer of how GLP-1 (and GIP/GLP-1) medications drive weight loss, how they act on appetite, satiety, and gastric emptying, what the STEP and SURMOUNT trials actually showed, and what that means realistically.